Plant Transcription Factor Database
Previous version: v3.0
Linum usitatissimum
M-type_MADS Family
Species TF ID Description
Lus10000400M-type_MADS family protein
Lus10000974M-type_MADS family protein
Lus10002763M-type_MADS family protein
Lus10003123M-type_MADS family protein
Lus10003481M-type_MADS family protein
Lus10003940M-type_MADS family protein
Lus10004150M-type_MADS family protein
Lus10004459M-type_MADS family protein
Lus10007371M-type_MADS family protein
Lus10007711M-type_MADS family protein
Lus10007713M-type_MADS family protein
Lus10011349M-type_MADS family protein
Lus10011456M-type_MADS family protein
Lus10011787M-type_MADS family protein
Lus10012449M-type_MADS family protein
Lus10012545M-type_MADS family protein
Lus10012656M-type_MADS family protein
Lus10014095M-type_MADS family protein
Lus10014578M-type_MADS family protein
Lus10014883M-type_MADS family protein
Lus10015271M-type_MADS family protein
Lus10015726M-type_MADS family protein
Lus10015766M-type_MADS family protein
Lus10016180M-type_MADS family protein
Lus10016563M-type_MADS family protein
Lus10016809M-type_MADS family protein
Lus10018493M-type_MADS family protein
Lus10018714M-type_MADS family protein
Lus10019089M-type_MADS family protein
Lus10019819M-type_MADS family protein
Lus10020511M-type_MADS family protein
Lus10020789M-type_MADS family protein
Lus10021399M-type_MADS family protein
Lus10021494M-type_MADS family protein
Lus10022316M-type_MADS family protein
Lus10022325M-type_MADS family protein
Lus10022505M-type_MADS family protein
Lus10022594M-type_MADS family protein
Lus10024347M-type_MADS family protein
Lus10024823M-type_MADS family protein
Lus10025872M-type_MADS family protein
Lus10026366M-type_MADS family protein
Lus10026613M-type_MADS family protein
Lus10028214M-type_MADS family protein
Lus10028473M-type_MADS family protein
Lus10028490M-type_MADS family protein
Lus10028653M-type_MADS family protein
Lus10029367M-type_MADS family protein
Lus10029556M-type_MADS family protein
Lus10030450M-type_MADS family protein
Lus10030663M-type_MADS family protein
Lus10030824M-type_MADS family protein
Lus10031073M-type_MADS family protein
Lus10032108M-type_MADS family protein
Lus10034464M-type_MADS family protein
Lus10035029M-type_MADS family protein
Lus10035456M-type_MADS family protein
Lus10036543M-type_MADS family protein
Lus10036761M-type_MADS family protein
Lus10037039M-type_MADS family protein
Lus10037166M-type_MADS family protein
Lus10037450M-type_MADS family protein
Lus10039704M-type_MADS family protein
Lus10040832M-type_MADS family protein
Lus10041548M-type_MADS family protein
Lus10042291M-type_MADS family protein
Lus10042918M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513